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Key points to consider when performing an oval gavage Oral gavage is performed, normally using an oesophageal-gastric cannula or catheter, to gently dose a precise amount of substance directly into the stomach at a slow enough rate to avoid regurgitation (Figure 5).[1, 7] Oral delivery may result in a slower substance onset of action compared with other administration routes.[7] Although gavage can be undertaken using rigid dosing cannulae, flexible catheters are preferred, and these are less likely to cause oesophageal trauma.[4] Inadvertent dosing into the lung may occur, and this usually results in the animal showing immediate signs of respiratory distress
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Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis
